发明名称 |
Therapeutic use of yessotoxins as human tumor cell growth inhibitors |
摘要 |
<p>The present invention relates to the therapeutic use of yessotoxins as human tumor cell growth inhibitors. The mechanism of action of yessotoxin (YTX) and analogs thereof is related to the activation of cellular phosphodiesterases and, accordingly, to the decrease of cAMP cytosolic levels. The result of this activation after administering YTX is human hepatocarcinoma cell growth inhibition. This cytotoxic effect of YTX on neoplasic cells can be used as a strategy to develop drugs useful in the treatment of tumor processes.
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申请公布号 |
EP1875906(A3) |
申请公布日期 |
2008.02.27 |
申请号 |
EP20070017630 |
申请日期 |
2004.07.21 |
申请人 |
UNIVERSIDADE DE SANTIAGO DE COMPOSTELA |
发明人 |
BOTANA LOPEZ, LUIS MIGUEL;ALFONSO RANCANO, AMPARO;RODRIGUEZ VIEYTES, MERCEDES;LOZA GARCIA, MARIA ISABEL |
分类号 |
A61K31/35;A61P11/06;A61P35/00;A61P37/08;C12Q;C12Q1/44;G01N21/64 |
主分类号 |
A61K31/35 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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