发明名称 |
Rapid assays for neurotransmitter transporters |
摘要 |
The invention describes the finding that 4-(4-dimethylaminostyrl)-N-methylpyridinium or ASP<SUP>+</SUP> is a fluorescent substrate that is transported by several neurotransmitter transporters. Provided are methods for the analysis of neurotransmitter transport and binding using ASP<SUP>+</SUP>. The invention also provides rapid methods for screening for modulators of neurotransmitter transport. As neurotransmitter transporter defects are associated with numerous neurological disorders, the invention also provides methods for treating neurotransmitter transport-associated defects/conditions using the modulators identified by the screening methods of the invention.
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申请公布号 |
US7318917(B2) |
申请公布日期 |
2008.01.15 |
申请号 |
US20030656897 |
申请日期 |
2003.09.05 |
申请人 |
VANDERBILT UNIVERSITY |
发明人 |
SCHWARTZ JOEL W.;BLAKELY RANDY D.;DEFELICE LOUIS |
分类号 |
A61K49/00;A61K38/43;C07D487/00;C07K14/01;C12N9/00;G01N33/94 |
主分类号 |
A61K49/00 |
代理机构 |
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地址 |
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