发明名称 |
METHOD FOR DIAGNOSING NON-SMALL CELL LUNG CANCERS BY tRNA-DIHYDROURIDINE SYNTHASE ACTIVITY OF URLC8 |
摘要 |
The present invention features a method for determining t-RNA dihydrouridine-synthase activity of a polypeptide and screening for modulators of t-RNA dihydrouridine-synthase activity. The present invention further provides methods or pharmaceutical compositions for preventing and/or treating non-small cell lung cancer (NSCLC) using such modulators. Furthermore, the present invention provides methods for diagnosing non-small cell lung cancer (NSCLC) using the t-RNA dihydrouridine-synthase activity of IMS-E21 (URLC8) protein as an index. The present invention further provides methods for predicting and prognosing lung squamous-cell carcinoma (SCC). |
申请公布号 |
EP1799854(A1) |
申请公布日期 |
2007.06.27 |
申请号 |
EP20050788285 |
申请日期 |
2005.09.21 |
申请人 |
ONCOTHERAPY SCIENCE, INC.;THE UNIVERSITY OF TOKYO |
发明人 |
NAKAMURA, YUSUKE;DAIGO, YATARO;NAKATSURU, SHUICHI |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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