发明名称 |
2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO[9,10-D]IMIDAZOLES AS MPGES-1 INHIBITORS |
摘要 |
The invention encompasses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
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申请公布号 |
CA2629527(A1) |
申请公布日期 |
2007.05.31 |
申请号 |
CA20062629527 |
申请日期 |
2006.11.21 |
申请人 |
MERCK FROSST CANADA INC. |
发明人 |
FRIESEN, RICHARD;YU, HONGPING;DUCHARME, YVES;GIROUX, ANDRE;MARTINS, EVELYN;WU, TOM;FRENETTE, RICHARD;COTE, BERNARD;GAGNON, MARC;CHAU, ANH |
分类号 |
C07D235/02;A61K31/4184;C07D401/04;C07D401/06;C07D405/06;C07D413/06 |
主分类号 |
C07D235/02 |
代理机构 |
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地址 |
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