发明名称 |
Methods for treatment of tumors and metastases using a combination of anti-angiogenic and immuno therapies |
摘要 |
The invention provides methods for treating tumors and tumor metastases in a mammal comprising administering, to a mammal in need of treatment, a therapeutic amount of an antagonist sufficient to inhibit angiogenesis in combination with a therapeutic amount of anti-tumor immunotherapeutic agent, such as a anti-tumor antigen antibody/cytokine fusion protein having a cytokine and a recombinant immunoglobulin polypeptide chain sufficient to elicit a cytokine-specific biological response. |
申请公布号 |
US2007036751(A1) |
申请公布日期 |
2007.02.15 |
申请号 |
US20060527029 |
申请日期 |
2006.09.26 |
申请人 |
EMD LEXIGEN RESEARCH CENTER CORP. |
发明人 |
LODE HOLGER N.;REISFELD RALPH A.;CHERESH DAVID A.;GILLIES STEPHEN D. |
分类号 |
A61K39/00;A61K39/395;A61K38/00;A61K38/19;A61K38/20;A61K38/21;A61K39/385;A61K45/06;A61K47/48;A61P35/00;C07K7/06;C07K7/64;C07K16/46 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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