| 摘要 |
A film-shaped therapeutic system comprising at least two layers connected with each other for transmucosal administration of active substances is disclosed, wherein said at least two layers includes a mucoadhesive layer which is mucoadhesive in an aqueous environment and a backing layer comprising at least one polyacrylate layer and serving as an active substance reservoir, wherein at least one layer of said at least two layers of said system contains an active substance, and wherein said mucoadhesive layer swells in an aqueous media but is insoluble or poorly soluble in the aqueous media and contains a polymer mixture comprising at least one hydrophile, mucoadhesive polymer embedded or dispersed in a polymer matrix comprising at least one polyvinyl alcohol.
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