Inhibition of the beta3 subunit of L-type Ca2+ channels

摘要

The present invention provides reagents and methods for identifying inhibitors of the L-type Ca²⁺ channel beta₃ protein, which has been demonstrated to be involved in calcium signaling, insulin secretion, and glucose homeostasis. The invention also provides therapeutics and methods for treating a subject with one or more of diabetes, insulin resistance, impaired insulin secretion, and impaired glucose homeostasis, involving the use of inhibitors of an L-type Ca²⁺ channel beta₃ subunit to provide a benefit to the subject.