发明名称 |
Desolvation process for the production of atorvastatin hemi-calcium essentially free of bound organic solvent |
摘要 |
The present invention provides processes for removing organic solvent from crystals of atorvastatin hemi-calcium containing organic solvent. In one process, the organic solvent is displaced by vapor diffusion of water in a vessel maintained at elevated humidity. In a second process, the organic solvent is removed by fluidized bed drying. The present invention further provides atorvastatin hemi-calcium containing 1% or less organic solvent, which can be obtained from atorvastatin hemi-calcium that has been crystallized from an organic solvent-containing solution by practice of the processes of the invention.
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申请公布号 |
US7122681(B2) |
申请公布日期 |
2006.10.17 |
申请号 |
US20030370424 |
申请日期 |
2003.02.19 |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES, LTD. |
发明人 |
ARONHIME JUDITH;MAIDAN-HANOCH DALIA |
分类号 |
C07D207/335;A61K31/40;A61P43/00;C07D207/34;C07D207/40;C07D207/416;C07F3/04 |
主分类号 |
C07D207/335 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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