发明名称 |
Modulation of telomere length by oligonucleotides having a G-core sequence |
摘要 |
Modified oligonucleotides having a GGG motif sequence and a sufficient number of flanking nucleotides to modulate the telomere length of a chromosome are provided. Methods of modulating telomere length of a mammalian chromosome in vitro and in vivo are also provided, as are methods for inhibiting the division of a malignant mammalian cell and for modulating the effects of cellular aging.
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申请公布号 |
US7067497(B2) |
申请公布日期 |
2006.06.27 |
申请号 |
US20020038335 |
申请日期 |
2002.01.02 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
HANECAK RONNIE C.;ANDERSON KEVIN P.;BENNETT C. FRANK;CHIANG MING-YI;BROWN-DRIVER VICKIE L.;ECKER DAVID J.;VICKERS TIMOTHY A.;WYATT JACQUELINE R. |
分类号 |
C07H21/04;A61K31/7115;A61K31/712;A61K31/7125;A61K38/00;C07H21/00;C12N15/113;C12N15/117;C12Q1/70 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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