| 发明名称 |
NOVEL MULTIMERIC CD40 LIGANDS, METHOD FOR PREPARING SAME AND USE THEREOF FOR PREPARING DRUGS |
| 摘要 |
The invention concerns a compound of formula (I), wherein Y represents a macrocycle whereof the cycle comprises 9 to 36 atoms, and is functionalized by three amine or COOH functions; R<SUB>c</SUB> represents a group of formula H-X<SUB>a</SUB>-X<SUB>b</SUB>-X<SUB>c</SUB>-X<SUB>d</SUB>-X<SUB>e</SUB>-(X<SUB>f</SUB>)<SUB>i</SUB>-, wherein i represents 0 or 1, X<SUB>a</SUB> is in particular selected among lysine, arginine, ornithine residues, X<SUB>b</SUB> is in particular selected among glycine, asparagine, L-proline or D-proline residues, X<SUB>c</SUB> et X<SUB>d</SUB> are in particular selected among tyrosine, phenylalanine or 3-nitrotyrosine residues, X<SUB>e</SUB> et X<SUB>f</SUB> are in particular selected among the following amino acid residues: NH<SUB>2</SUB>-(CH<SUB>2</SUB>)<SUB>n</SUB>-COOH, n ranging from 1 to 10 or NH<SUB>2</SUB>-(CH<SUB>2</SUB>-CH<SUB>2</SUB>-O)<SUB>m</SUB>-CH<SUB>2</SUB>CH<SUB>2</SUB>COOH, m ranging from 3 to 6, provided that one at least of the amino acid residues X<SUB>a</SUB>, X<SUB>b</SUB>, X<SUB>c</SUB> and X<SUB>d</SUB> is different from the corresponding amino acid in the sequence of the natural CD40 <SUP>143</SUP>Lys-Gly-Tyr- Tyr<SUP>146</SUP> fragment |
| 申请公布号 |
WO2006064133(A2) |
申请公布日期 |
2006.06.22 |
| 申请号 |
WO2005FR03146 |
申请日期 |
2005.12.15 |
| 申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;GUICHARD, GILLES;FOURNEL, SYLVIE, VICTORINE, LUCIENNE;CHALOIN, OLIVIER;TROUCHE, NATHALIE;WIECKOWSKI, SEBASTIEN;HOEBEKE, JOHAN |
发明人 |
GUICHARD, GILLES;FOURNEL, SYLVIE, VICTORINE, LUCIENNE;CHALOIN, OLIVIER;TROUCHE, NATHALIE;WIECKOWSKI, SEBASTIEN;HOEBEKE, JOHAN |
| 分类号 |
C07K14/525;A61K38/04;C07K14/705 |
主分类号 |
C07K14/525 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
