| 摘要 |
PROBLEM TO BE SOLVED: To provide a new compound having not only antihistamine effects but also antiinflammatory effects. SOLUTION: A urasil derivative represented by general formula (I) or a pharmacologically acceptable salt thereof is used for medicinal applications. In formula (I), R<SP>1</SP>is a hydrogen atom, a substituted or unsubstituted 1-4C alkyl group, or a substituted or unsubstituted 7-10C aralkyl group; R<SP>2</SP>is a hydrogen atom or a 1-4C alkyl group; Ar<SP>1</SP>is a substituted or unsubstituted aromatic group, or a substituted or unsubstituted aromatic heterocyclic group; Ar<SP>2</SP>and Ar<SP>3</SP>are each a substituted or unsubstituted phenyl group, or a substituted or unsubstituted monocyclic aromatic heterocyclic group, and may form a third ring by a group linking to both Ar<SP>2</SP>and Ar<SP>3</SP>; X is a methine (CH) group or a nitrogen atom; Y is a single bond or an oxygen atom when X is a methine group, and is a single bond when X is a nitrogen atom; Z is a hydrogen atom or a hydroxy group when X is a methine group and Y is a single bond, and is a hydrogen atom when X is a methine group and Y is an oxygen atom or when X is a nitrogen atom (and Y is a single bond); and m is 2-6. COPYRIGHT: (C)2006,JPO&NCIPI
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