DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH KALLIKREIN 1 (KLK1)

摘要

The invention provides a human KLK1 which is associated with the endocrine system and hormone disorders, cardiovascular disorders, metabolic diseases, inflammatory diseases, gastrointestinal and liver diseases, cancer disorders, hematological disorders, muscle-skeleton disorders, reproduction disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of endocrine system and hormone disorders, cardiovascular disorders, metabolic diseases, inflammatory diseases, gastrointestinal and liver diseases, cancer disorders, hematological disorders, muscle-skeleton disorders, reproduction disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of KLK1 as well as pharmaceutical compositions comprising such compounds.