MODULATION OF EPIDERMAL GROWTH FACTOR HETERODIMER ACTIVITY
摘要
Provided is a method for screening a plurality of compounds for an ability to bind to a heterodimer of EGFR and another ERBB family member. Also provided are compounds that bind to heterodimers of EGFR and another ERBB family member, and methods of using the identified compounds to suppress the growth of a tumor associated with EGFR heterodimer activity in a subject.
申请公布号
WO2005079434(A3)
申请公布日期
2006.04.06
申请号
WO2005US04968
申请日期
2005.02.17
申请人
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;THREADGILL, DAVID;LEE, DAEKEE