发明名称 |
Methods of crystal precipitation |
摘要 |
Crystals of paroxetine hydrochloride ½-hydrate are allowed to separate out by adding water to a solution or suspension comprising paroxetine hydrochloride and a polar organic solvent which contains no water or at most 60% by weight of water to adjust the water content to at least 70% by weight when crystals of paroxetine hydrochloride ½-hydrate are allowed to separate out in a water-containing polar organic solvent. Crystals of paroxetine hydrochloride ½-hydrate being not colored in pink can be allowed to separate out in the presence of hydrogen chloride when crystals of paroxetine hydrochloride ½-hydrate are allowed to separate out in water or a water-containing polar organic solvent.
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申请公布号 |
US2006048696(A1) |
申请公布日期 |
2006.03.09 |
申请号 |
US20050527317 |
申请日期 |
2005.03.10 |
申请人 |
YAMAZAKI SHIGEYA;YOSHIKAWA TAICHI |
发明人 |
YAMAZAKI SHIGEYA;YOSHIKAWA TAICHI |
分类号 |
H01L21/322;C07D263/58;C07D405/12;C30B15/14 |
主分类号 |
H01L21/322 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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