| 摘要 |
This invention relates to methods for predicting replication capacity of a virus based on its genotype. It also relates to determining epistatic relationships between viral mutations, including those that affect replication capacity. It also relates to identifying targets for antiviral therapy by identifying mutations associated with altered replication capacity. The methods are useful for determining the replication capacity of an HIV based on its genotype and for identifying previously unknown interactions among viral molecules or between viral molecules and host cell molecules that are essential to viral infection and/or replication. By identifying such interactions, novel targets for antiviral therapy can be identified.
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