发明名称 |
Antitumor effect potentiators |
摘要 |
When used concurrently with an antitumor agent, a compound having a Rho kinase inhibitory activity, such as (R)-(+)-N-(4-pyridyl)-4-(1-aminoethyl)benzamide, reinforces an antitumor effect of the antitumor agent and is useful as an antitumor effect potentiator. Particularly, a compound having a Rho kinase inhibitory activity used with an antitumor agent in combination can reduce the dose of the antitumor agent, which in turn affords provision of a sufficient effect and/or reduction of side effects.
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申请公布号 |
US6930115(B2) |
申请公布日期 |
2005.08.16 |
申请号 |
US20030311928 |
申请日期 |
2003.02.05 |
申请人 |
MITSUBISHI PHARMA CORPORATION |
发明人 |
FUJII AKIHIRO;TANAKA HIROSHI;OTSUKI MAKIO;KAWAGUCHI TAKAFUMI;OSHITA KOUICHI |
分类号 |
A61K31/27;A61K31/335;A61K31/337;A61K31/415;A61K31/437;A61K31/4375;A61K31/44;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/444;A61K31/4453;A61K31/4545;A61K31/50;A61K31/501;A61K31/505;A61K31/519;A61K31/7048;A61K33/24;A61K45/06;A61P35/00;A61P43/00;(IPC1-7):A61K31/437;A61K31/440 |
主分类号 |
A61K31/27 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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