| 摘要 |
Compounds of formula (1) and pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R8 is H, -OR12 -NR12R13, -NR12C(O)R13, cyano, -C(O)OR13 -SR12, -(CR13R14)t(4-10 membered heterocyclic ), wherein t is an integer from 0 to 5, or C1-C6 alkyl, wherein said heterocyclic and alkyl moieties are optionally substituted by 1 to 3 R6 substituents; R9 is -(CR13R14)t(imidazolyl) wherein t is an integer from 0 to 5 and said imidazolyl moiety is optionally substituted by 1 or 2 R6 substituents; provided that where R6 is not -(CR13R14),(C3-C10 cycloalkyl), wherein t is an integer from 0 to 5, then R8 is triazolyl optionally substituted by 1 or 2 R6 groups, or at least one of R3, R4 and R5 is -CH-NOR12 or -S(O)j R12 wherein j is an intege r from 0 to 2. The compounds of formula (1) are useful in the treatment of hyperproliferative disorders, such as cancer, in mammals. The invention also relates to pharmaceutical compositions containing the compounds of formula (1) and to methods of inhibiting abnormal cell growth, including cancer, in a mammal by administering the compounds of formula (1) to a mammal requiring such treatment.
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