| 摘要 |
A pharmaceutical composition comprising modafinil in the form of particles, wherein greater than 5% to about 50% of the cumulative total of the modafinil particles in the composition have a particle size greater than about 200 microns as determined by a U.S. Sieve No. 75. The present inventors have unexpectedly determined that the pharmaceutical compositions of the invention exhibit comparable stability, dissolution, and bioavailability as compared to Provigil(R) which is a commercially-available modafinil formulation.
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