发明名称 |
Inhibitors for de novo-RNA polymerases and methods of identifying targets for same |
摘要 |
A polymerase inhibitor has first moiety coupled to a second moiety via an optional linker in which the first moiety binds to an initiation nucleotide binding site of a polymerase and forms at least two hydrogen bonds with an RNA template strand that is associated with the polymerase, and in which the second moiety comprised a compound that binds to a site proximal to the nucleotide binding site of the polymerase and thereby increases the affinity of the polymerase inhibitor to the polymerase.
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申请公布号 |
US6906190(B2) |
申请公布日期 |
2005.06.14 |
申请号 |
US20020330369 |
申请日期 |
2002.12.27 |
申请人 |
RIBAPHARM INC. |
发明人 |
YAO NANHUA;AN HAOYUN;APPLEBY TODD;NILAR SHAHUL;DING YILI;HONG ZHI |
分类号 |
A61K31/52;C07D473/18;(IPC1-7):C07D473/16;C07D473/30;C07D473/34;A61P31/14 |
主分类号 |
A61K31/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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