SERINE PROTEASES, NUCLEIC ACIDS ENCODING SERINE ENZYMES AND VECTORS AND HOST CELLS INCORPORATING SAME

摘要

The present invention provides novel serine proteases, novel genetic materia l encoding these enzymes, and proteolytic proteins obtained from Micrococcinea e spp., including but not limited to Cellulomonas spp. and variant proteins developed therefrom. In particular, the present invention provides protease compositions obtained from a Cellulomonas spp, DNA encoding the protease, vectors comprising the DNA encoding the protease, host cells transformed wit h the vector DNA, and an enzyme produced by the host cells. The present invention also provides cleaning compositions (e.g., detergent compositions) , animal feed compositions, and textile and leather processing compositions comprising protease(s) obtained from a Micrococcineae spp., including but no t limited to Cellulomonas spp. In alternative embodiments, the present inventi on provides mutant (i.e., variant) proteases derived from the wild-type proteas es described herein. These mutant proteases also find use in numerous applications.