发明名称 |
Lactic acid bacteria and their cellular components inducing immunoregulatory function, and method of obtaining the same |
摘要 |
To provide a microorganism and an ingredient thereof that contribute to prevention and treatment of immune diseases including allergy, autoimmune diseases and inflammatory bowel diseases (e.g., large-intestinal ulcer), a method of effectively selecting the microorganism, andamethodofefficientlyinducingimmunoregulatory cells that play an important role on maintaining immunological homeostasis using the microorganism or the ingredient thereof. The present invention provides a Lactococcus and an ingredient thereof which induce production of IL-10 from mammalian dendritic or spleen cells, a method of obtaining the microorganism or the ingredient thereof by co-culturing a microorganism such as Lactococcus strains with mammalian dendritic or spleen cells to select a microbial cell having a high IL-10 production ability, a method of selecting the microorganism or the ingredient thereof by co-culturing an intestinal epithelial cell with a microorganism such as the lactic acid bacteria and selecting the cells on the basis of a caspase-1 activity and the ability of inducing the production of IL-18, and a food product or material and an animal feeding stuff or medical and pharmaceutical products which contain the lactic acid bacteria as an effective ingredient. <IMAGE> |
申请公布号 |
EP1538198(A2) |
申请公布日期 |
2005.06.08 |
申请号 |
EP20040106138 |
申请日期 |
2004.11.29 |
申请人 |
NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES;INCORPORATED ADMINISTRATIVE AGENCY NATIONAL AGRICULTURE AND BIO-ORIENTED RESEARCH ORGANIZATION |
发明人 |
TSUJI, NORIKO;KIMOTO, HIROMI |
分类号 |
A23K1/16;A23C9/00;A23C19/00;A23C19/032;A23K1/00;A23L1/03;A23L1/30;A61K35/74;A61P1/04;A61P37/02;A61P37/08;C12N1/20;C12P21/02;C12Q1/00;C12Q1/02 |
主分类号 |
A23K1/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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