发明名称 |
METHODS OF LOWERING LIPID LEVELS IN A MAMMAL |
摘要 |
This invention relates to methods for lowering lipid levels in mammals using compounds that inhibit advanced glycation endproducts (AGEs), LR-9, LR-74 and LR-90. These compounds, which inhibit non-enzymatic protein glycation, also inhibit the formation of advanced lipoxidation endproducts (ALEs) on target proteins by trapping intermediates in glycoxidation and lopoxidation and inhibiting oxidation reactions important in the formation of AGEs and ALEs. |
申请公布号 |
WO2005044251(A2) |
申请公布日期 |
2005.05.19 |
申请号 |
WO2004US35440 |
申请日期 |
2004.10.27 |
申请人 |
CITY OF HOPE;RAHBAR, SAMUEL;FIGAROLA, JAMES LESTER |
发明人 |
RAHBAR, SAMUEL;FIGAROLA, JAMES LESTER |
分类号 |
A61K31/19;A61K31/195;A61K31/47;A61K31/4706 |
主分类号 |
A61K31/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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