8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYCLO-[4,3,0]-NONANE-8-YL)-6- FLU ORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID OF CRYSTALLINE MODIFICATION D AND MEDICINAL AGENT ELICITING EFFECT AGAINST PATHOGENIC MICROORGANISMS

摘要

FIELD: organic chemistry, medicine, pharmacy. ^ SUBSTANCE: invention describes 8-cyclo-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-[4.3.0]-nonane-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid of the formula (I): ^ in crystalline modification D and a medicinal agent based on thereof eliciting effect against pathogenic microorganisms. The prepared crystalline form of compound of the formula (I) shows low hygroscopicity and can be processed to galenic preparations easily and it has the highest filled density and satisfied fluidity. ^ EFFECT: valuable properties of agent. ^ 4 cl, 7 dwg, 1 ex