GAPPED OLIGOMERIC COMPOUNDS HAVING LINKED BICYCLIC SUGAR MOIETIES AT THE TERMINI

摘要

The present invention relates to bicyclic nucleosides and oligomeric compoun ds comprising at least one such nucleoside. These oligomeric compounds typicall y have enhanced binding affinity and nuclease resistance properties compared t o unmodified oligomeric compounds. The oligomeric compounds are useful, for example, for investigate and therapeutic purpose.