| 摘要 |
Compounds for topically influencing the activity of dipeptidyl peptidase of the general formula B-A-C is disclosed, wherein: A is an amino acid having at least one functional group in the side chain; B is a chemical compound covalently bound to a functional group of the side chain of A, chosen from the group consisting of (a) oligopeptides having a chain length of up to 20 amino acids, (b) homopolymers of glycine consisting of up to 6 glycine monomers, and (c) polyethylene glycols having molar masses of up to 20 000 g/mol, optionally substituted organic amines, amides, alcohols, acids or aromatic compounds having from 8 to 50 carbon atoms; and C is thiazolidine, pyrrolidine, cyanopyrrolidine, hydroxyproline, dehydroproline or piperidine group amide-bonded to A, with H-Glu[NH(CH2)7CONH(CH2)3NHZ]pyrrolidine and H-Lys[CO(CH2)3NHSO2Pfp]pyrrolidine being excluded, and at least one customary adjuvant appropriate for the site of action. Also disclosed is the use of these compounds for targeted intervention in local immunological processes (chemotaxis, inflammatory processes, autoimmune diseases), as well as effective and targeted treatment of pathophysiological and physiological processes related thereto (psoriasis, periodontitis, arthritis, allergies, inflammation), inter alia. (62) Divided out of 517157
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