ANTIBODY CDR POLYPEPTIDE SEQUENCES WITH RESTRICTED DIVERSITY

摘要

The invention provides variant CDRs comprising highly restricted amino acid sequence diversity. These polypeptides provide a flexible and simple source of sequence diversity that can be used as a source for identifying novel antige n binding polypeptides. The invention also provides these polypeptides as fusi on polypeptides to heterologous polypeptides such as at least a portion of phag e or viral coat proteins, tags and linkers. Libraries comprising a plurality o f these polypeptides are also provided. In addition, methods of and compositio ns for generating and using these polypeptides and libraries are provided.