发明名称 |
Alkaloid that inhibits biosynthesis of mycotoxins and method for screening for mycotoxin inhibitors |
摘要 |
The present invention provides an alkaloid compound that is an inhibitor of mycotoxin biosynthesis. The alkaloid is an alkenyl piperidine amide wherein the alkenyl is a C18 alkenyl with one or more double bonds. The alkaloid inhibits transcription of the fungus genes nor-1, tri5, and ipnA. The present invention further provides a method for identifying compounds, which inhibit biosynthesis of aflatoxin in Aspergillus spp. and deoxynivalenol in Gibberella spp. without inhibiting growth of the fungus in vitro.
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申请公布号 |
US2005026953(A1) |
申请公布日期 |
2005.02.03 |
申请号 |
US20040943742 |
申请日期 |
2004.09.17 |
申请人 |
BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY |
发明人 |
TRAIL FRANCES;HAMMERSCHMIDT RAYMOND;LINZ JOHN E.;XU HAIXIN;VELASQUEZ LUIS;ANNIS SEANNA L. |
分类号 |
A61K31/4453;C07D295/185;C12N15/80;(IPC1-7):A61K31/445;C07D211/60 |
主分类号 |
A61K31/4453 |
代理机构 |
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