发明名称 |
Use of chimeric nucleases to stimulate gene targeting |
摘要 |
Gene targeting is a technique to introduce genetic change into one or more specific locations in the genome of a cell. For example, gene targeting can introduce genetic change by modifying, repairing, attenuating or inactivating a target gene or other chromosomal DNA. In one aspect, this disclosure relates to methods and compositions for gene targeting with high efficiency in a cell. This disclosure also relates to methods of treating or preventing a genetic disease in an individual in need thereof. Further disclosed are chimeric nucleases and vectors encoding chimeric nucleases.
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申请公布号 |
US2005026157(A1) |
申请公布日期 |
2005.02.03 |
申请号 |
US20030656531 |
申请日期 |
2003.09.05 |
申请人 |
BALTIMORE DAVID;PORTEUS MATTHEW |
发明人 |
BALTIMORE DAVID;PORTEUS MATTHEW |
分类号 |
A61K48/00;C07H21/04;C12N9/22;C12N15/90;C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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