发明名称 |
Sammensætninger, der omfatter blokkere af L-DOPA renal-celle overförsel, til behandlingen af Parkinsons sygdom |
摘要 |
A pharmaceutical composition for the treatment of Parkinson's disease comprises L-DOPA and at least one compound capable of blocking the L-DOPA renal cell outward transfer pathway; said blocking compound being chose from (a) a flavonoid phenyl benzopyran derivative; (b) a trans-stilbene derivative; or (c) phloretin [3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone]. The composition may also comprise an inhibitor of the enzyme amino acid decarboxylase (AADC), such a carbidopa or benserazide, and/or an inhibitor of the enzyme catechol-O-methyl transferase (COMT), such as entacapone or tolcapone. The composition is preferably administered in soli form and the L-DOPA may be administered simultaneously or sequentially with the L-DOPA renal cell outward transfer blocking compound. |
申请公布号 |
DK1267853(T3) |
申请公布日期 |
2005.01.10 |
申请号 |
DK20010931528T |
申请日期 |
2001.03.13 |
申请人 |
PORTELA & CA., S.A. |
发明人 |
SOARES-DA-SILVA, PATRICIO. |
分类号 |
A61K31/00;A61P25/16;(IPC1-7):A61K31/00 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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