| 摘要 |
The present invention pertains to the use of a compounds for the manufacture of a medicament for use in the treatment of a proliferative condition, wherein the compounds have the following formula: wherein: each of R<B2>, R<B3>, R<B4>, and R<B5 >is independently -H, -OH, or -OMe; each of R<1 >and R<2 >is independently: -H, optionally substituted C1-4alkyl, or optionally substituted C5-20aryl; R<A3 >is -H, -OH, -OC(=O)R<E>, -OS(=O)2OH, or -OP(=O)(OH)2; R<E >is: -H, optionally substituted C1-6alkyl, optionally substituted C3-20heterocyclyl, or optionally substituted C5-20aryl; or a pharmaceutically acceptable salt, solvate, amide, ester, ether, chemically protected form, or prodrug thereof. The present invention also pertains to such compounds, pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, for both diagnosis and treatment of, for example, proliferative conditions, such as cancer, and inflammatory conditions.
|
