发明名称 |
POLYHYDROXY PHENOLS AND THEIR USE IN BINDING P-SELECTIN |
摘要 |
Polyhydroxy phenols, which are non-peptidic mimetics of galloyl peptides, an d a process for the preparation of gallic acid derivatives using a gallic-acid providing moiety are provided as well as polyhydroxy phenol-containing pharmaceutical and nutraceutical compositions. The use of polyhydroxy phenol s as a medicament and especially for the manufacture of a medicament for the prevention, treatment or diagnosis of a disease or a condition, wherein P- selectin is involved, is provided. The same compounds can also be used as targeting tools to P-selectin expressing cells or tissues in a composition, further comprising an active compound in a vehicle.
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申请公布号 |
CA2527141(A1) |
申请公布日期 |
2004.12.09 |
申请号 |
CA20042527141 |
申请日期 |
2004.05.07 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
BONNEFOY, ARNAUD;VAN BERKEL, THEODORUS JOSEPHUS CORNELIS;HOYLAERTS, MARC FLORIMOND;KUIPER, JOHAN;APPLEDOORN, CHANTAL CATHARINA MARIA;BIESSEN, ERIK ANNA LEONARDUS |
分类号 |
A61K31/05;A61K9/107;A61K9/127;A61K31/192;A61K31/352;C07C69/96;C07C237/22;C07D209/20 |
主分类号 |
A61K31/05 |
代理机构 |
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地址 |
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