| 摘要 |
Compounds of formula (I) are disclosed, and their preparation and pharmaceutical compositions containing them. The compounds are CB2 cannabinoid receptor agonists, in which: Ar represents: a) a phenyl mono-, di- or trisubstituted by one or more groups chosen from: a halogen atom, a (C1-C4)alkyl, a trifluoromethyl, an amino, a nitro, a hydroxyl, a (C1-C4)alkoxy, a (C1-C4)alkylsulphanyl or a (C1-C4)alkylsulphonyl; b) a naphthyl which is unsubstituted or substituted once or twice by a halogen atom, a (C1-C4)alkyl or a trifluoromethyl; A represents a C2-C6 alkylene radical; Y represents a group chosen from SR4, SOR4, SO2R4, SO2NR5R6, N(R7)SO2R4, OR4 or NR7SO2NR5R6; R1, R3 and R'3 represent, each independently of one another, hydrogen, a hydroxyl, a halogen atom, a (C1-C4)alkyl, a trifluoromethyl or a (C1-C4)alkoxy; R2 represents hydrogen or a (C1-C4)alkyl; R4 represents a (C1-C4)alkyl or a trifluoromethyl; R5 and R6 each independently represent hydrogen or a (C1-C4)alkyl; R7 represents hydrogen or a (C1-C4)alkyl and its optional salts and/or its solvates. The compound is useful in treating or preventing the following diseases or conditions: disorders of the immune system, diseases of the connective tissue, allergic diseases, viral or bacterial diseases, inflammatory diseases, pain, eye conditions, pulmonary conditions, diseases of the central nervous system and neurogenerative diseases, cardiovascular diseases, renal ischaemia, cancers, gastrointestinal diseases or obesity.
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