发明名称 |
INTRAVENOUS NANOPARTICLES FOR TARGENTING DRUG DELIVERY AND SUSTAINED DRUG RELEASE |
摘要 |
<p>Provided are poly(lactic-co-glycolic acid) (PLGA) and poly(lactic acid) (PLA) nanoparticles that encapsulate a low molecular weight and water-soluble drug and can deliver the drug to target legion sites where the particles gradually release the drug over a prolonged period of time. The nanoparticles are prepared by allowing the low-molecular, water-soluble and non-peptide drug to interact with a metal ion so as to make the drug hydrophobic, encapsulating the hydrophobicized drug into PLGA or PLA nanoparticles, and allowing a surfactant to be adsorbed onto the surface of the particles.</p> |
申请公布号 |
WO2004084871(A1) |
申请公布日期 |
2004.10.07 |
申请号 |
WO2004JP03246 |
申请日期 |
2004.03.11 |
申请人 |
LTT BIO-PHARMA CO., LTD.;ISHIHARA, TSUTOMU;MIZUSHIMA, YUTAKA |
发明人 |
ISHIHARA, TSUTOMU;MIZUSHIMA, YUTAKA |
分类号 |
A61K9/51;(IPC1-7):A61K9/51 |
主分类号 |
A61K9/51 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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