The CE-SELEX procedure of the present invention is a novel selection procedure that utilizes capillary electrophoresis (CE) in combination with conventional SELEX selection procedures. CE-SELEX, for the first time, allows selection to be performed in free solution. Performing selection against a target in free solution yields aptamers with improved affinity and/or improved selectivity toward target molecules for use as improved pharmaceuticals and diagnostic agents.
申请公布号
WO03102212(A9)
申请公布日期
2004.09.16
申请号
WO2003US16796
申请日期
2003.05.29
申请人
REGENTS OF THE UNIVERSITY OF MINNESOTA;BOWSER, MICHAEL, T.;MENDONSA, SHAUN, D.