ULTRASOUND CONTRAST AGENTS AND PROCESS FOR THE PREPARATION THEREOF
摘要
Method for preparing a lyophilized matrix and, upon reconstitution of the same, a respective injectable contrast agent comprising a liquid aqueous suspension of gas-filled microbubbles stabilized predominantly by a phospholipid. The method comprises preparing an emulsion from an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and subsequently reconstituted in an aqueous suspension of gas-filled microbubbles. The method allows to obtain suspensions comprising microbubbles having a relatively small diameter and a narrow size distribution.
申请公布号
WO2004069284(A2)
申请公布日期
2004.08.19
申请号
WO2004IB00243
申请日期
2004.02.03
申请人
BRACCO RESEARCH SA;SCHNEIDER, MICHEL;BUSSAT, PHILIPPE;YAN, FENG;GUILLOT, CHRISTIAN
发明人
SCHNEIDER, MICHEL;BUSSAT, PHILIPPE;YAN, FENG;GUILLOT, CHRISTIAN