发明名称 |
PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING MULTIDRUG RESISTANT CANCER |
摘要 |
<p>The invention relates to a pharmaceutical composition comprising i) ketotifen or an analog thereof and ii) a chemotherapeutic drug subject to multi-drug resistance by P-gp, such as doxorubicin or an analog thereof. The pharmaceutical composition is useful for treating cancer. The pharmaceutical composition is also useful for i) preventing or treating multi-drug resistance in a subject or ii) preventing a chemotherapeutic drug subject to multi-drug resistance by P-gp induced cardiac tissue damage in a subject, such as doxorubicin or an analog thereof. The invention relates to a pharmaceutical composition comprising i) ketotifen or an analog thereof and ii) a chemotherapeutic drug subject to multi-drug resistance by P-gp, such as doxorubicin or an analog thereof. The pharmaceutical composition is useful for treating cancer. The pharmaceutical composition is also useful for i) preventing or treating multi-drug resistance in a subject or ii) preventing a chemotherapeutic drug subject to multi-drug resistance by P-gp induced cardiac tissue damage in a subject, such as doxorubicin or an analog thereof.</p> |
申请公布号 |
WO2004064838(A1) |
申请公布日期 |
2004.08.05 |
申请号 |
WO2004CA00033 |
申请日期 |
2004.01.19 |
申请人 |
UNIVERSITY HEALTH NETWORK;BERGER, STUART, A.;ZHANG, YICHENG |
发明人 |
BERGER, STUART, A.;ZHANG, YICHENG |
分类号 |
A61K31/4436;A61K31/4535;A61K31/704;A61K45/06;(IPC1-7):A61K31/453 |
主分类号 |
A61K31/4436 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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