发明名称 |
IMMUNOGENIC COMPOSITION COMPRISING AN IL-13 ELEMENT AND T CELL EPITOPES, AND ITS THERAPEUTIC USE |
摘要 |
The present invention relates to isolated immunogens and their use in the treatment of diseases that are treatable with neutralisation of IL-13, such as COPD, asthma and atopic disorders such as hayfever, contact allergies and atopic dermatitis. In particular the invention relates to the neutralisation of the biological effects of IL-13 by raising an immune response against the IL-13 by vaccination of a mammal with immunogens comprising the native or mutated amino acid sequence of IL-13, and foreign T-helper epitopes either inserted in, or attached to the IL-13 sequence or present in carrier polypeptides. Also provided by the present invention are DNA vaccines that comprise a polynucleotide sequence that encodes the immunogens of the present invention. The invention further relates to pharmaceutical compositions comprising such immunogens and their use in medicine and to methods for their production. |
申请公布号 |
WO2004019974(A3) |
申请公布日期 |
2004.07.22 |
申请号 |
WO2003GB03703 |
申请日期 |
2003.08.28 |
申请人 |
GLAXO GROUP LIMITED;ASHMAN, CLAIRE;ELLIS, JONATHAN, HENRY |
发明人 |
ASHMAN, CLAIRE;ELLIS, JONATHAN, HENRY |
分类号 |
A61K39/00;A61P11/00;A61P37/08;C07K14/54 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|