发明名称 |
CANCER THERAPY USING BETA GLUCAN AND ANTIBODIES |
摘要 |
The present invention relates to methods of using neutral soluble glucan and monoclonal antibodies for antitumor therapy. Neutral soluble Beta (1,3; 1,6) glucan (NSG) enhances the tumoricidal activity of the innate immune system by binding to the C3 complement protein receptor CR3. The glucan does not stimulate the induction of inflammatory cytokines. Also described are methods of using whole glucan particles (WGP) as an immunomodulator by inducing a shift from a Th2 response to the Thl response, leading to an enhanced antitumor cytotoxic T-cell response. |
申请公布号 |
WO2004030613(A2) |
申请公布日期 |
2004.04.15 |
申请号 |
WO2003US27975 |
申请日期 |
2003.09.04 |
申请人 |
UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.;ROSS, GORDON, D. |
发明人 |
ROSS, GORDON, D. |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|