发明名称 |
DETERMINATION OF BONE-SIALOPROTEIN IN BODILY FLUIDS FOR ONCOLOGICAL PROBLEMS |
摘要 |
<p>The invention relates to antibodies or a plurality of antibodies against human bone sialoprotein (BSP), characterized in that the antibodies bind to epitopes which are present only in human bone sialoprotein from tumor cells, the post-translational glycosylation of which is modified or incomplete in the region of amino acids of 120 to 135, containing the amino acids TGLAA (SEQ ID NO: 2), in comparison with normal bone sialoprotein from bones. The antibodies are put to use in an immunoassay for the diagnosis and prognosis of tumor diseases, in particular the diagnosis and prognosis of bone metastases in the case of primary breast carcinoma.</p> |
申请公布号 |
EP1399482(A2) |
申请公布日期 |
2004.03.24 |
申请号 |
EP20020758218 |
申请日期 |
2002.06.06 |
申请人 |
IMMUNDIAGNOSTIK AG |
发明人 |
ARMBRUSTER, FRANZ PAUL;KARMATSCHEK, MARKUS;PAULSSON, MATS |
分类号 |
G01N33/574;A61K39/395;A61K47/48;A61P19/00;A61P35/00;C07K14/51;C07K16/18;C07K16/32;G01N33/577;G01N33/68;(IPC1-7):C07K16/18 |
主分类号 |
G01N33/574 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|