发明名称 |
BETA-LACTAMASE INHIBITOR PRODRUG |
摘要 |
<p>Prodrugs of 6-ß-hydroxymethylpenicillanic acid sulfone having the structure wherein R is H or methyl, and solvates thereof, are disclosed. Also disclosed are pharmaceutical compositions comprising a prodrug of the present invention, or a solvate thereof, an optional beta-lactam antibiotic and at least one pharmaceutically acceptable carrier. Further disclosed is a method for increasing the therapeutic effectiveness of a beta-lactam antibiotic in a mammal by administering an effective amount of a betalactam antibiotic and an effectiveness-increasing amount of a prodrug of the present invention, or a solvate thereof. Additionally disclosed is a method for treating a bacterial infection in a mammal by administering a therapeutically effective amount of a pharmaceutical composition of the present invention to a mammal in need thereof.</p> |
申请公布号 |
WO2004018484(A1) |
申请公布日期 |
2004.03.04 |
申请号 |
WO2003IB03582 |
申请日期 |
2003.08.11 |
申请人 |
PFIZER PRODUCTS INC.;MARFAT, ANTHONY;MCLEOD, DALE, GORDON |
发明人 |
MARFAT, ANTHONY;MCLEOD, DALE, GORDON |
分类号 |
A61P43/00;C07D499/861;A61K31/43;A61P31/04;C07D;C07D499/00;C07D499/48;C07D499/86;C07D499/897;(IPC1-7):C07D499/00 |
主分类号 |
A61P43/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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