发明名称 |
METHODS AND COMPOSITIONS FOR MODULATING AND DETECTING WISP ACTIVITY |
摘要 |
Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of HAS2, HA, CD44 or RHAMM by native human WISP-1 polypeptide in at least one type of mammalian cell. The invention also provides methods for in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with native WISP-1 polypeptides. |
申请公布号 |
WO2004003158(A2) |
申请公布日期 |
2004.01.08 |
申请号 |
WO2003US20407 |
申请日期 |
2003.06.28 |
申请人 |
GENENTECH, INC.;DESNOYER, LUC;FILVAROFF, ELLEN |
发明人 |
DESNOYER, LUC;FILVAROFF, ELLEN |
分类号 |
A61K39/00;C07K14/47;C07K16/22;C07K16/30 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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