发明名称 |
POLYMORPHISM OF SOATI USEFUL FOR IDENTIFYING RISK OF DEVELOPING ALZHEIMER'S DISEASE |
摘要 |
Based on the unexpected association of a SOAT1 gene polymorphism with reduced genetic risk for a neurodegenerative disease, in particular Alzheimer's disease, the present invention provides a method of diagnosing or prognosticating such a disease, or determining the propensity or predisposition of a subject to develop such a disease. The method comprises detecting the presence or absence of a single nucleotide polymorphism in the SOAT1 gene which encodes the enzmye ACAT1, acyl-coenzyme A: cholesterol acyltransferase 1. |
申请公布号 |
WO03098222(A1) |
申请公布日期 |
2003.11.27 |
申请号 |
WO2003EP05190 |
申请日期 |
2003.05.16 |
申请人 |
UNIVERSITAET ZUERICH;PAPASSOTIROPOULOS, ANDREAS;WOLLMER, AXEL;NITSCH, ROGER;HOCK, CHRISTOPH |
发明人 |
PAPASSOTIROPOULOS, ANDREAS;WOLLMER, AXEL;NITSCH, ROGER;HOCK, CHRISTOPH |
分类号 |
C12Q1/48;C12Q1/68;G01N33/68 |
主分类号 |
C12Q1/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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