Process for production of crystals of an adjuvant substance, crystals obtained thereby and pharmaceutical preparations containing them

摘要

The process for making crystals of an adjuvant substance for pharmaceutical compositions, which have a predetermined average particle size in a predetermined size range and a maximum particle size that does not exceed a predetermined maximum value, includes subjecting a supersaturated solution containing the adjuvant substance to a wet milling by a wet milling apparatus while crystallizing, in order to obtain a primary particle suspension. Crystals obtained according to this process and pharmaceutical preparations containing them are also described.