N-(aminoacyl)azolidines as inhibitors of dipeptidyl peptidase IV prepared from an alpha,omega-diamino acid derivative or an amino dicarboxylic acid derivative

摘要

Compounds of formula (1), their pharmaceutical compositions, or pharmaceutically acceptable salts thereof, that are useful in the treatment of, inter alia, type 2 diabetes are disclosed, wherein R1 is H or CN; X1 is S, O, SO2 or CH2; X2 is O, S or CH2; X3 is NR5 or a carbonyl or thiocarbonyl group; and R4 is R6R7N, R8(CH2)qOC(=O), R8(CH2)qOC(=S), R6R7NC(=O), R6R7NC(=S), R8(CH2)qC(=O), R8(CH2)qC(=S) or R8(CH2)qSO2, m is 1-3 and n is 0-4, all other variables are as defined in the specification.