| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a new non-human animal model such as mice for modeling neurodegenerative diseases including amyloidopathies, especially AD (Alzheimer's disease). <P>SOLUTION: The new animal model for amyloidopathies, especially Alzheimer's disease overexpressing human BACE and human APP London. This new animal model exhibits several aspects of amyloidopathy and has utility in developing specific and general therapies for amyloidopathies. Moreover, this animal model can be used for screening methods to identify new anti-amyloidogenic compounds and for testing their therapeutic effect. A method for producing said double transgenic animals, cells and cell lines derived from these animals, and a kit comprising these cells for screening compounds useful for amyloidopathies, are also provided, respectively. Moreover, a method for the evaluation of the in vivo effects of beta-secretase activity on A-beta peptide generation, amyloidosis, neurodegeneration and AD pathology in these animals is also provided. <P>COPYRIGHT: (C)2004,JPO |
