INDUCTION OF HEPATOCYTE PROLIFERATION IN VITRO BY INHIBITION OF CELL CYCLE INHIBITORS

摘要

The present invention provides methods of inducing proliferative and differentiative mammalian hepatocytes, or survival of differentiative mammalian hepatocytes, in vitro comprising contacting the hepatocytes with protein kinase A (PKA) inhibitor. Figure 2B shows DNA synthesis in hepatocytes cultured on collagen film or gel with H89 or DMSO.