PROCESS FOR ASYMMETRIC INTRAMOLECULAR [3+2] CYCLO- ADDITION OF HYDRAZONES

摘要

Intramolecular [3+2] cycloaddition of a hydrazone derivative can be carried out under mild conditions with high stereoselectivity and in high yield by subjecting a hydrazone derivative to reaction in the presence of an asymmetric catalyst system obtained by mixing a zirconium alkoxide represented by the general formula (I): Zr(OR)4 [wherein R is an optionally substituted hydrocarbon group] with a binaphthol derivative represented by the general formula (II): (II) [wherein Y1 and Y2 are each independently hydrogen or halogeno, with the proviso that at least either of Y1 and Y2 is halogeno].