| 摘要 |
The present invention relates to detoxified immunogenic derivatives of Clostridium perfringens beta-toxin or an immunogenic fragment thereof that have as a characteristic that they carry a mutation in the beta-toxin amino acid sequence, not found in the wild-type beta-toxin amino acid sequence. The invention also relates to genes encoding such beta-toxins, as well as to expression systems expressing such beta-toxins. Moreover, the invention relates to bacterial expression systems expressing a native beta-toxin. Finally, the invention relates to vaccines based upon detoxified immunogenic derivatives of Clostridium perfringens beta-toxin, and methods for the preparation of such vaccines.
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