发明名称 |
Polymer conjugates of protein kinase C inhibitors |
摘要 |
The invention provides polymer conjugates of protein kinase C (PKC) inhibitors comprising a polymer, such as poly(ethylene glycol), covalently attached to a PKC inhibitor, such as a bisindolylmaleimide molecule. The linkage between the polymer and the PKC inhibitor is preferably hydrolytically degradable. The invention also includes a pharmaceutical composition comprising a polymer conjugate of a PKC inhibitor and a method of treating any condition responsive to a PKC inhibitor by administering a polymer conjugate of the invention.
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申请公布号 |
US2003143185(A1) |
申请公布日期 |
2003.07.31 |
申请号 |
US20020282915 |
申请日期 |
2002.10.29 |
申请人 |
SHEARWATER CORPORATION |
发明人 |
BENTLEY MICHAEL DAVID;ZHAO XUAN |
分类号 |
C07D403/14;A61K31/404;A61K45/00;A61K47/48;A61P3/10;A61P9/00;A61P11/06;A61P17/06;A61P25/28;A61P29/00;A61P31/12;A61P35/00;A61P37/00;A61P43/00;C08G65/333;(IPC1-7):A61K31/785;A61K31/705;A61K38/16;C07K14/00;C08G69/00 |
主分类号 |
C07D403/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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