发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING LIGHT-INDUCED INACTIVATION OF BIOLOGICAL REAGENTS |
摘要 |
<p>Disclosed is a fluorescent conjugate comprising a biological reagent, a fluorescent molecule, and a means for impeding phototoxic degradation of the biological reagent. The impeding means can be a cross-linking substance having a long molecular distance, whereby the cross-linking substance links the fluorescent molecule and the biological reagent; a quencher of singlet oxygen; a quencher of a free radical; or a combination thereof. Also disclosed is a solution comprising a fluorescent conjugate of a biological reagent and a fluorescent molecule together with an oxygen depleting system.</p> |
申请公布号 |
EP0972194(B1) |
申请公布日期 |
2003.07.02 |
申请号 |
EP19980913406 |
申请日期 |
1998.04.06 |
申请人 |
BIOSITE DIAGNOSTICS INC. |
发明人 |
BEUCHLER, KENNETH, F.;MCPHERSON, PAUL, H.;SUNDQUIST, ALFRED, R. |
分类号 |
G01N33/533;G01N33/543;G01N33/58;(IPC1-7):G01N33/53 |
主分类号 |
G01N33/533 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|